Clinical trial SPRINTT (Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies)

Multi-componenT Treatment strategies = physical activity + diet

This project will give us the opportunity with Regulators, Academia and other stakeholders, to agree on the therapeutic indication, endpoints and Clinical Trial methodology which will allow to develop innovative treatments for this currently underdiagnosed geriatric condition.

This will be the first non competitive interventional European clinical trial in frail sarcopenic older patients using physical activity as benchmark for future studies with investigational drugs.

 

What are the Objectives of this project? 

To validate an interventional paradigm for identifying at-risk individuals living in the community and evaluate innovative therapeutic interventions against physical frailty and mobility disability, through:

1. Creating an operational definition of at-risk (sub-)populations with undisputable unmet therapeutic need
2. Qualification of muscular anabolism and catabolism biomarkers in at-risk (sub-) populations
3. Validation and implementation of practical clinical methodologies for testing clinically meaningful interventions for the screening, prevention of Physical Frailty and Sarcopenia and  its complications (falls, mobility disability, hospitalization, institutionalization)
4. Developing scientific and regulatory Consensus on these 3 strategic objectives: therapeutic indication, biomarkers and development clinical methodology
5. Developing a health-economic model of physical Frailty and Sarcopenia in a real life setting

• Listing ID: 414
• National Dietetic Association: FRANCE - French Association of Nutritionist Dietitians - AFDN, Association Française des Diététiciens Nutritionistes
• EFAD Education Associate Member: none or other than from the list
• EuDAP key objectives: Objective 2. Promote the gains of a healthy diet and nutritional support throughout the life course
• Target audience: Health professionals, Senior Citizens
• Type: Research
• Participating countries or institutions: The five-year project is the result of a rich multiple collaboration between sixteen major research institutions in the geriatric field across Europe:
  
  Università Cattolica del Sacro Cuore(lead), Le Centre Hospitalier Universitaire de Toulouse, Univerzita Karlova v Praze, Helsingin yliopisto, Servicio Madrileno de Salud , Universitaetsmedizin Goettingen, Georg-August-Universitaet - Stiftung Oeffentlichen Rechts , Université Paris Descartes , Università degli Studi di Firenze , Friedrich- Alexander- Universität Erlangen-Nürnberg , Uniwersytet Jagiellonski , Istituto Nazionale di Riposo e Cura per Anziani-INRCA ; small medium size companies: Caretek s.r.l., EU-Open S.R.l, Roessingh Research and Development ; and five EFPIA members: Sanofi(lead), GSK, Novartis, Servier and Lilly.
• Read more (link): http://www.mysprintt.eu/en

1. Check all listings by this user
2. Add to favourites

Contact details

Ronenn Roubenoff, Project coordinator, Novartis Institutes for Biomedical ResearchFrance *****

Contact listing owner

Please, login to contact this listing owner.